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The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients (CROSBI ID 256675)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Belavić, Matija ; Sotošek Tokmadžić, Vlatka ; Fišić, Elizabeta ; Brozović Krijan, Antonija ; Strikić, Nedjeljko ; Lončarić Katušin, Mirjana ; Žunić, Josip The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients // Minerva anestesiologica, 84 (2018), 9; 1032-1043

Podaci o odgovornosti

Belavić, Matija ; Sotošek Tokmadžić, Vlatka ; Fišić, Elizabeta ; Brozović Krijan, Antonija ; Strikić, Nedjeljko ; Lončarić Katušin, Mirjana ; Žunić, Josip

engleski

The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients

BACKGROUND: The endothelial glycocalyx is located on the luminal side of blood vessels and maintains vessel integrity. This study analysed how various dosages of infusion affected the secretion of atrial natriuretic peptide (ANP) and potential glycocalyx damage in patients undergoing laparoscopic cholecystectomy. We hypothesised that the liberal administration of Ringer's solution during the operation can cause iatrogenic hypervolemia with releasing of ANP and glycocalyx damage. METHODS: The study included 90 patients with American Society of Anesthesiologists' (ASA) class I and II, in good cardiopulmonary health, who were assigned to one of three groups: Restrictive group, which received 1 mL/kg/hr intraoperatively and six hours postoperatively ; Low liberal group, which received 5 mL/kg/hr of Ringer's solution intraoperatively and six hours postoperatively and High liberal group, which received 15 mL/kg/hr intraoperatively and 10 mL/kg/hr six hours postoperatively. We measured patients' concentrations of glycocalyx constituents, ANP, markers of kidney and liver function, C- reactive protein (CRP), and albumine at three time points. We also measured noinvasive hemodynamics, the correlation between ANP secretion and the concentration of glycocalyx components. RESULTS: We found a significantly higher concentrations of hyaluronic acid and syndecan-1 and more ANP secretion in the High liberal group than in the other groups. We also observed a positive correlation between ANP secretion and glycocalyx constituent concentration. Markers of kidney and liver function were normal, suggesting preservation of splanchnic perfusion and global hemodynamics. CONCLUSIONS: Measuring the endothelial glycocalyx constituents in circulating blood could be a marker of intraoperative volume overload during laparoscopic operations.

Atrial natriuretic factor ; Cholecystectomy ; laparoscopic ; Fluid therapy ; Glycocalyx ; Heparan sulfate proteoglycans ; Hyaluronic acid

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Podaci o izdanju

84 (9)

2018.

1032-1043

objavljeno

0375-9393

1827-1596

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost