engleski

Correlation of soluble Fas/APO-1 level in cerebrospinal fluid and lesion volume in acute stroke patients-preliminary report

Background and aim: Cerebral ischemia studies in animal model have indicated that apoptosis-programmed cell death, migh be contributor to neuronal death. The aim of this study was to correlate the level of soluble (s) Fas/APO-1 (apoptosis suppressing protein) in CSF, with lesion volume in acute ischemic stroke patients. Methods: Six male patients (mean age 63&plusmn ; 10 years) with first acute ischemic stroke, verified by clinial examination and CT scan were included in the study. Patients with history of severe infection, congestive heart failure, autoimmune and malignant disease were not included. Soluble Fas/APO-1 level in CSF was determinated by ELISA on day 3 of disease onset. Volume of ischemic lesions on CT scans (performed on the same day) was measured by own software. Statistical analysis was performed by Kendall&#8217 ; s tau test. Results: The CSF level of sFas/APO-1 in acute stroke patients of the observed group, ranged from 0 to 1, 8 U/ml. The volume of ischemic lesions on CT scan, ranged from 0, 21 to 47, 72 ml. There was statistically significant correlation between CSF level of sFas/APO-1 and volume of ischemic lesion on CT scans in stroke patients (correlation coefficient 0, 6 ; p= 0, 045). Conclusion: The preliminary results demonstrate correlation between CSF level of sFas/APO-1 and volume of ischemic lesions on CT scans, suggesting possible pathophysiological contribution of apoptosis in acute stroke patients.

Fas/APO-1

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