The novel ketoprofenamides - synthesis and spectroscopic characterization (CROSBI ID 104605)
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Podaci o odgovornosti
Zovko, Marijana ; Zorc, Branka ; Jadrijević-Mladar Takač, Milena ; Metelko, Biserka ; Novak, Predrag
engleski
The novel ketoprofenamides - synthesis and spectroscopic characterization
Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid P-alanine. The structures of synthesized compounds were characterized by means of IR, H-1 and C-13 NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.
ketoprofen; amides; synthesis; characterization
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