Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Alternative models for toxicity testing of xenobiotics (CROSBI ID 109010)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Kniewald, Jasna ; Kmetič, Ivana ; Gaurina-Srček, Višnja ; Kniewald, Zlatko Alternative models for toxicity testing of xenobiotics // Arhiv za higijenu rada i toksikologiju, 56 (2005), 2; 195-204-x

Podaci o odgovornosti

Kniewald, Jasna ; Kmetič, Ivana ; Gaurina-Srček, Višnja ; Kniewald, Zlatko

engleski

Alternative models for toxicity testing of xenobiotics

Alternatives to whole-animal testing include endpoint assays, cell and tissue cultures, the use of tissue slices, toxicokinetic modeling, and structure-activity relationships and databases. The use of in vitro systems (subcellular fractions, cell lines, primary cell cultures, tissue slices, organ cultures, etc.) as research tools in toxicology is widespread. In the last few years apoptosis phenomena should be followed by a very precise intracellular changes where through programmed cell death a cell can be removed from a population. In vitro systems are ideally suited to investigations of the molecular, cellular and physiological mechanisms of chemical-induced toxicity, which cannot readily be studied in vivo, for known target organ and target species toxicity studies, and for answering specific questions about toxic effects. The main justification for developing in vitro toxicity tests is that they will make toxicology a more scientifically based practice. It is becoming increasingly apparent that the development and incorporation of stepwise testing strategies, combining experimental data from a range of alternative methods (physicochemical techniques, quantitative structure-activity relationships - QSAR, metabolic and kinetic modelling, and in vitro tests), provides the most effective way forward for trying to predict toxicity, while at the same time reducing the number of laboratory animals used for testing purposes.

in vitro methods; alternative models; toxicity testing

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

56 (2)

2005.

195-204-x

objavljeno

0004-1254

Povezanost rada

Biotehnologija

Indeksiranost