Spectroscopic and biological study of Pd(II) complexes with monoethyl 2-quinolylmethylphosphonate (CROSBI ID 463236)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Tušek-Božić, Ljerka ; Furlani, Ariella ; Scarcia, Vito
engleski
Spectroscopic and biological study of Pd(II) complexes with monoethyl 2-quinolylmethylphosphonate
Continuing our research on palladium complexes with organophosphorus chelate ligands, the synthesis as well as some spectroscopic and biological properties of the molecular and ionic palladium(II) complexes with the monoethyl 2-quinolylmethylphosphonate (2-mqmp) have been reported. Dihalogenopalladium complexes containing N-bonded monodentate ligand in a trans square-planar fashion were obtained by interaction of 2-mqmp with PdX_4^2- (X=Cl, Br) either in the methanolic or in the aqueous medium at pH~3.5. The neutral complex where 2-mqmp acts as a bidentate chelate ligand through the quinoline nitrogen and the phosphonic acid group was isolated at pH~6. From the HX acidic medium were isolated the ion-pair salt complexes containing the protonated quinoline ligand as cation and the trihalogenopalladium complex as anion. The in vitro cytostatic activity of all the complexes was evaluated against an epidermoid human carcinoma (KB) and against murine leukeamia (L1210) cell lines.
palladium(II) complex; quinolylmethylphosphonate; spectral study; antitumor activity
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Podaci o prilogu
B47-B47-x.
1996.
objavljeno
Podaci o matičnoj publikaciji
Feiters, M. C ; Hagen, W. R ; Veeger, C.
Nijmegen: NSR Center, Nijmegen
Podaci o skupu
Third European Conference on Bio-Inorganic Chemistry
poster
04.08.1996-10.08.1996
Noordwijkerhout, Nizozemska