engleski

Alcohol-related Cancers and Genetic Susceptibility in Europe (ARCAGE) Study – Croatian Results

Introduction: In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck cancer in 13 centres in 9 European countries, Croatia included. The ARCAGE study database with approximately 2500 case-control pairs is currently the largest head and neck cancer patients database in Europe. Aim: the aim of the present study was to estimate the risk of smoking and alcohol consumption in Croatian head and neck cancer patients recruited in scope of the ARCAGE study. Methods: 54 cases (45 males, 9 females) and 46 controls (37 males, 9 females) were recruited from University Hospital Dubrava and Merkur University hospital. A blood sample and a lifestyle questionnaire were collected from all subjects. Data were analysed by logistic regression analysis. Results: The distribution of cases was: 43 oral, 9 pharyngeal and 2 laryngeal cancer cases. Ever-smokers had a 3.7-fold higher cancer risk (adjusted OR 3.72 (CI 1.10-12.61)) compared to never-smokers. The adjusted odds ratio for ever-alcohol consumption was 1.64 (0.28-9.80). Conclusion: The results are in keeping with previously published data from other countries. In addition to enabling the estimation of the effect of smoking and alcohol consumption in Croatian head and neck cancer patients, the data on Croatian subjects form a part of the ARCAGE study database, which will provide an opportunity for a high-resolution analysis of environmental risk factors, genetic susceptibility, and their interactions in the carcinogenesis of head and neck cancer.

karcinomi glave i vrata; pušenje; konzumacija alkohola; genetska sklonost

nije evidentirano