Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity (CROSBI ID 137220)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Đilović, Ivica ; Rubčić, Mirta ; Vrdoljak, Višnja ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Piantanida, Ivo ; Cindrić, Marina
engleski
Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4- phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the possibility of DNA binding by intercalation, especially for here studied naphthalene derivatives. However, here presented DNA binding studies excluded this mode of action. Physicochemical and structural properties of novel derivatives were compared with previously studied analogues, taken as reference compounds, revealing distinctive differences. In addition, novel thiosemicarbazone derivatives (1, 2 and 5-8) clearly display stronger antiproliferative activity on five tumor cell lines than the reference compounds 3 and 4, which supports their further investigation as potential antitumor agents.
thiosemicarbazone ; antitumor evaluation ; UV/vis spectroscopy ; DNA binding
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Podaci o izdanju
16 (9)
2008.
5189-5198
objavljeno
0960-894X
1464-3405
10.1016/j.bmc.2008.03.006
Povezanost rada
Kemija, Temeljne medicinske znanosti