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Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity (CROSBI ID 137220)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Đilović, Ivica ; Rubčić, Mirta ; Vrdoljak, Višnja ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Piantanida, Ivo ; Cindrić, Marina Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity // Bioorganic & medicinal chemistry letters, 16 (2008), 9; 5189-5198. doi: 10.1016/j.bmc.2008.03.006

Podaci o odgovornosti

Đilović, Ivica ; Rubčić, Mirta ; Vrdoljak, Višnja ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Piantanida, Ivo ; Cindrić, Marina

engleski

Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity

The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4- phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the possibility of DNA binding by intercalation, especially for here studied naphthalene derivatives. However, here presented DNA binding studies excluded this mode of action. Physicochemical and structural properties of novel derivatives were compared with previously studied analogues, taken as reference compounds, revealing distinctive differences. In addition, novel thiosemicarbazone derivatives (1, 2 and 5-8) clearly display stronger antiproliferative activity on five tumor cell lines than the reference compounds 3 and 4, which supports their further investigation as potential antitumor agents.

thiosemicarbazone ; antitumor evaluation ; UV/vis spectroscopy ; DNA binding

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Podaci o izdanju

16 (9)

2008.

5189-5198

objavljeno

0960-894X

1464-3405

10.1016/j.bmc.2008.03.006

Povezanost rada

Kemija, Temeljne medicinske znanosti

Poveznice
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