Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Assessment of Steroid Disruption and Metal Concentrations in Human Placenta: Effects of Cigarette Smoking (CROSBI ID 35324)

Prilog u knjizi | izvorni znanstveni rad

Piasek, Martina ; Henson, Michael C. ; Blanuša, Maja ; Kostial, Krista Assessment of Steroid Disruption and Metal Concentrations in Human Placenta: Effects of Cigarette Smoking // Smoking and Health Research Frontiers / Fong, Calvin B. (ur.). Haupauge (NY): Nova Science Publishers, 2007. str. 119-161

Podaci o odgovornosti

Piasek, Martina ; Henson, Michael C. ; Blanuša, Maja ; Kostial, Krista

engleski

Assessment of Steroid Disruption and Metal Concentrations in Human Placenta: Effects of Cigarette Smoking

Tobacco smoking is an unhealthy lifestyle linked with infertility and fetal abnormalities. Both first- and second-hand tobacco smoke can result in ill effects on female reproductive integrity and disturbances in the maternal-embryo/feto-placental functional unit. Numerous harmful substances from tobacco smoke can pass the placental barrier or accumulate in placental structures. Cigarette smoke contains several thousands of chemicals and approximately 30 metal ions, including cadmium, arsenic, lead, nickel, chromium, aluminum, antimony, copper, iron, and radioactive elements. Many metals are highly reactive and contribute to the production of oxidative stress, a starting point of toxic and carcinogenic effects of tobacco smoke. In the general population, cigarette smoke is the chief environmental source of cadmium, a confirmed human carcinogen. By affecting woman’ s health and the internal environment of her descendant(s), toxic metals may cause immediate and delayed ill effects on virtually all organ systems. Women of childbearing age and growing infants are prone to deficiencies of essential elements (iron, zinc, copper, calcium) and thus are especially sensitive to toxic-essential metal interactions. During pregnancy, toxic metals can compromise fetal health directly in utero, by passing the placental barrier, and indirectly, by accumulation in the placenta and inhibition of nutrient transfer to the fetus. Toxic metals can interfere with principal placental functions, maintenance of pregnancy and fetal viability, by affecting the production of placental hormones. Their accumulation in the placenta may compromise prevention of placental-fetal rejection by maternal immune system and fetal response to antigen exposure in utero. Only a few studies so far have validated the concept of placental steroid disruption due to metal exposure. Cadmium ions accumulate in human placental (trophoblast) cells where they suppress progesterone release without apparent inhibition of syncytial development. Increase in placental cadmium is commensurate with a decrease in placental progesterone concentrations in women exposed to cigarette smoke during pregnancy. Animal studies support the findings of cadmium-induced ovarian and placental steroid disruption during pregnancy. A concomitant low iron diet has an additive effect on cadmium-induced placental steroid disruption. Human placenta can be used as a 'dual purpose specimen' for monitoring harmful substances in both the maternal and internal fetal environment when epidemiological variables for evaluation of exposure conditions are considered. Assessment of placental function by steroid disruption as an indicator of fetal distress in utero may serve as a useful noninvasive test for evaluation of risk for infant health in relation to prenatal exposure to common pollutants in environmental tobacco smoke.

placenta; cadmium concentration, metal ions, steroid disruption; tobacco smoke; active smoking, passive smoking; fetal distress in utero; risk for infant health

Chapter in thematic book upon publisher's invitation.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

119-161.

objavljeno

Podaci o knjizi

Smoking and Health Research Frontiers

Fong, Calvin B.

Haupauge (NY): Nova Science Publishers

2007.

1-60021-480-0

Povezanost rada

Javno zdravstvo i zdravstvena zaštita