engleski

Outcome of patients with epileptic seizures as the first symptom of acute stroke

Early poststroke seizures result from cellular biochemical dysfunction leading to epileptic discharges. Whether seizures worsen the outcome of the stroke is uncertain. We compared the outcome of patients with epileptic seizures as the first symptom of acute stroke and patients without epileptic seizures. We analyzed 2256 patients with acute stroke admitted to the University Hospital from year 2001 to 2005. In the study group there were 84 patients (3.7%), 46 (54.8%) women and 38 (45.2%) men, mean age 74.6 ± ; 11.8 years with epileptic seizures as the first symptom of acute stroke. The control group comprised of 100 patients with acute stroke without epileptic seizures admitted during the same period, randomized, age and sex matched to the study group. We analyzed the outcome of the patients in both groups after 6 and 12 months follow-up. In the study group after 6 months follow-up 23/75 (30.6%) patients died. 9 patients were not available. After 12 months follow-up 1/52 (1.9%) patient additionally died. In the control group 13/100 (13.0%) patients died after 6 and 32/100 (32.0%) after 12 months follow-up. We used Pearson Chi-Square test and found statistically significant difference in outcome between study and control group after 6 months follow-up in women (p=0.005). We found no difference in outcome after 6 months in men (p=0.245), and after 12 months follow-up in women (p=0.175) and men (p=0.562). There is increased mortality during 6 months follow-up in women with epileptic seizures as the first symptom of acute stroke.

epileptic seizures; stroke

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