Cu(II) complexes of nitrogen ligand - oligopeptide conjugates as potential artificial nucleases (CROSBI ID 540542)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kirin, Srećko I. ; Happel, Christoph M. ; Klein, Christoph ; Metzler-Nolte, Nils
engleski
Cu(II) complexes of nitrogen ligand - oligopeptide conjugates as potential artificial nucleases
In this work, the nitrogen ligand bpa (bispicolylamine) was conjugated to the oligopeptide nls (nuclear localization signal, PKKKRKV) by solid phase peptide synthesis, yielding bioconjugate 2. The binding of 2 and Cu(II) was studied by UV/VIS and MS and compared with the isolated well-defined simple bpa complex 1Cu. The results indicate similar structural features of 1Cu and the in situ prepared metal bioconjugate 2Cu. At present our efforts are focused on the evaluation of nuclease activity of bioconjugate 2Cu.
artificial enzymes; copper(II) complexes; peptides; solid phase peptide synthesis
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Podaci o prilogu
261-262.
2004.
objavljeno
Podaci o matičnoj publikaciji
Proceedings of SPS-8, The eight international symposium: Innovation and perspectives in solid phase synthesis and combinatorial libraries
Epton, Rodger
Kingston: Mayflower Worldwide Ltd.
Podaci o skupu
Nepoznat skup
poster
29.02.1904-29.02.2096