Effects of oral cadmium exposure during pregnancy on maternal and foetal element distribution and steroidogenesis in rats (CROSBI ID 546978)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Katić, Anja ; Piasek, Martina ; Lazarus, Maja ; Kljaković-Gašpić, Zorana ; Jurasović, Jasna
engleski
Effects of oral cadmium exposure during pregnancy on maternal and foetal element distribution and steroidogenesis in rats
In recent years cadmium has been recognized of having potency to act as metalloestrogen in mammals. We investigated earlier effects of parenteral exposure to cadmium (total dose 5 mg Cd/kg s.c.) in pregnant rats and found that it caused perturbations in element concentrations in maternal and foetal compartments, serum oestradiol concentration, and placental progesterone production (BioMetals 17:1-14, 2004 ; In: TEMA 10, Pt.V/1:809-12, 2000). We initiated new investigation aimed at assessing effects of cadmium exposure on steroidogenesis and element distribution in mother rats and foetuses. Female rats (Wistar) are exposed to 50 ppm Cd (as CdCl2xH2O) in demineralised water (Cd-exposed) or demineralised water (Control) from gestation day (GD)1-GD19. Calculated daily dose based on drink intake is 6.4+/-0.3 mg Cd/kg b.wt. On GD19 mother rats are killed (by exsanguination from heart and abdominal aorta in parenteral anaesthesia). Preliminary results showed increased cadmium concentrations in all analysed tissues of Cd-exposed rats except whole foetuses. Zinc concentrations were decreased in placental tissue and whole foetus. Oral cadmium exposure during pregnancy disrupts foetal zinc concentrations, an essential element for protein synthesis and organ development. Steroid disruption is yet to be evaluated.
cadmium; element distribution; foetus; gestation; placenta; rats; steroids
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Podaci o prilogu
S55-S55.
2008.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Toxicology letters
Tsatsakis, Aristidis M ; Liesivuori, Jyrki
Elsevier
0378-4274
Podaci o skupu
45th Congress of the European Societies of Toxicology, EUROTOX 2008
poster
05.10.2008-08.10.2008
Rodos, Grčka
Povezanost rada
Javno zdravstvo i zdravstvena zaštita