Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Alcohol-related cancers and genetic susceptibility in Europe : the ARCAGE project : study samples and data collection (CROSBI ID 151367)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lagiou, P. ; Georgila, C. ; Minaki, P. ; Ahrens, W. ; Pohlabeln, H. ; Benhamou, S. ; Bouchardy, C. ; Slamova, A. ; Schejbalova, M. ; Merletti, F. et al. Alcohol-related cancers and genetic susceptibility in Europe : the ARCAGE project : study samples and data collection // European journal of cancer prevention, 18 (2009), 1; 76-84

Podaci o odgovornosti

Lagiou, P. ; Georgila, C. ; Minaki, P. ; Ahrens, W. ; Pohlabeln, H. ; Benhamou, S. ; Bouchardy, C. ; Slamova, A. ; Schejbalova, M. ; Merletti, F. ; Richiardi, L. ; Kjaerheim, K. ; Agudo, A. ; Castellsague, X. ; Macfarlane, T.V. ; Macfarlane, G.J. ; Talamini, R. ; Barzan, L. ; Canova, C. ; Simonato, L. ; Lowry, R. ; Conway, D.I. ; McKinney, P.A. ; Znaor, Ariana ; McCartan, B.E. ; Healy, C. ; Nelis, M. ; Metspalu, A. ; Marron, M. ; Hashibe, M. ; Brennan, P.J.

engleski

Alcohol-related cancers and genetic susceptibility in Europe : the ARCAGE project : study samples and data collection

Cancers of the upper aerodigestive tract (UADT) include those of the oral cavity, pharynx (other than nasopharynx), larynx, and esophagus. Tobacco smoking and consumption of alcoholic beverages are established causes of UADT cancers, whereas reduced intake of vegetables and fruits are likely causes. The role of genetic predisposition and possible interactions of genetic with exogenous factors, however, have not been adequately studied. Moreover, the role of pattern of smoking and drinking, as well as the exact nature of the implicated dietary variables, has not been clarified. To address these issues, the International Agency for Research on Cancer initiated in 2002 the alcohol-related cancers and genetic susceptibility (ARCAGE) in Europe project, with the participation of 15 centers in 11 European countries. Information and biological data from a total of 2304 cases and 2227 controls have been collected and will be used in a series of analyses. A total of 166 single nucleotide polymorphisms of 76 genes are being studied for genetic associations with UADT cancers. We report here the methodology of the ARCAGE project, main demographic and lifestyle characteristics of the cases and controls, as well as the distribution of cases by histology and subsite. About 80% of cases were males and fewer than 20% of all cases occurred before the age of 50 years. Overall, the most common subsite was larynx, followed by oral cavity, oropharynx, esophagus and hypopharynx. Close to 90% of UADT cancers were squamous cell carcinomas. A clear preponderance of smokers and alcohol drinkers among UADT cases compared with controls was observed.

upper aerodigestive cancers; case-control study

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

18 (1)

2009.

76-84

objavljeno

0959-8278

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Indeksiranost