engleski

Influence of 2-deoxy-D-glucose on cell growth of the yeast Saccharomyces cerevisiae

2-deoxy-D-glucose (2-DOG) causes two main effects in the yeast Saccharomyces cerevisiae: the first is glucose repression and the second is an inhibitory effect caused by a disturbance of cell metabolism. In this work we have studied both effects of 2-DOG on yeast metabolism and their influence on substrate uptake and growth of biomass. The effect of glucose repression on galactose grown cells was observed at 2-DOG concentration of 20 mg/l, and growth was stopped completely at concentration of 50 mg/l. The inhibitory mode of action occurred at a concentrations higher than 300 mg/l.

S. cerevisiae ; cell growth ; 2-deoxy-D-glucose ; inhibitory effects ; glucose repression

nije evidentirano