engleski

Expression of oxalate transporters in rat renal proximal tubules is sex-dependent

In the mammalian proximal tubule, oxalate secretion is mediated by concerted action of sodium-independent sulphate transporter Sat1, localized in the cell basolateral membrane, and chloride/formate exchanger CFEX, localized in the cell brush-border membrane. Both transporters exhibit the male-dominant sex differences in their expression. A higher abundance of oxalate transporters in the male kidneys may contribute to formation and higher incidence of oxalate urolithiasis in male rats and humans, but the nature and extent of this contribution for each transporter is unknown.

anion transporters; gender differences; kidney; nephron; protein expression

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