Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation (CROSBI ID 87490)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Breljak, Davorka ; Boranić, Milivoj ; Horvat, Štefica
engleski
Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation
Dipeptide Tyr-Gly and tripeptide Tyr-Gly-Gly representing the NH2-end of the Met-enkephalin molecule inhibited the GM-colony formation in clonal cultures of mouse bone marrow cells. Intermediate or COOH-terminal dipeptides Gly-Gly and Phe-Met respectively were inneffective. The suppressive effects were not abolished by opioid receptor blocking agent naloxone and only partly so by depletion of the accessory (adherent) cells. The results are congruent with idea that neuropeptides and products of their enzymatic degradation participate in the regulation of hematopoiesis.
bone marrow cells; CFU-GM; methionine enkephalin; oligopeptides; naloxone
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Podaci o izdanju
13 (1)
2000.
13-19
objavljeno
0394-6320
2058-7384
10.1177/039463200001300102
Povezanost rada
Kliničke medicinske znanosti