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izvor podataka: crosbi

Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation (CROSBI ID 87490)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Breljak, Davorka ; Boranić, Milivoj ; Horvat, Štefica Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation // International journal of immunopathology and pharmacology, 13 (2000), 1; 13-19. doi: 10.1177/039463200001300102

Podaci o odgovornosti

Breljak, Davorka ; Boranić, Milivoj ; Horvat, Štefica

engleski

Oligopeptide fragments of the enkephalin molecule interfere with hematopoietic cell colony formation

Dipeptide Tyr-Gly and tripeptide Tyr-Gly-Gly representing the NH2-end of the Met-enkephalin molecule inhibited the GM-colony formation in clonal cultures of mouse bone marrow cells. Intermediate or COOH-terminal dipeptides Gly-Gly and Phe-Met respectively were inneffective. The suppressive effects were not abolished by opioid receptor blocking agent naloxone and only partly so by depletion of the accessory (adherent) cells. The results are congruent with idea that neuropeptides and products of their enzymatic degradation participate in the regulation of hematopoiesis.

bone marrow cells; CFU-GM; methionine enkephalin; oligopeptides; naloxone

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nije evidentirano

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Podaci o izdanju

13 (1)

2000.

13-19

objavljeno

0394-6320

2058-7384

10.1177/039463200001300102

Povezanost rada

Kliničke medicinske znanosti

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