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Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells (CROSBI ID 474673)

Prilog sa skupa u zborniku | izvorni znanstveni rad | domaća recenzija

Breljak, Davorka ; Boranić, Milivoj Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells // Current Studies in Biotechnology, Volume I. -Biomedicine / Kniewald, Zlatko i sur. (ur.). Zagreb: Croatian Society for Biotechnology, 2000. str. 85-87-x

Podaci o odgovornosti

Breljak, Davorka ; Boranić, Milivoj

engleski

Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells

This study explored the effect of thiorphan, a synthetic inhibitor of membrane metallopeptidase (enkephalinase EC 3.4.24.11, CD10) on proliferation of the human erythroleukemia cell line K562. The proliferation was measured after the incubation of the cells with thiorphan for 1 and 3 or 2, 4 and 6 days. A colorimetric assay based on the cleavage of the tetrazolium salt WST-1 by mitochondrial dehidrogenases in viable cells was used for that purpose. Thiorphan did not affect the proliferation of K562 cells, although the cells do express CD10. Thus, the CD10 membrane metallopeptidase seems not to play a significant role in the control of K562 cells proliferation rate.

erythroleukemia cell line; CD10; thiorphan; cell proliferation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

85-87-x.

2000.

objavljeno

Podaci o matičnoj publikaciji

Current Studies in Biotechnology, Volume I. -Biomedicine

Kniewald, Zlatko i sur.

Zagreb: Croatian Society for Biotechnology

Podaci o skupu

Nepoznat skup

poster

29.02.1904-29.02.2096

Povezanost rada

Kliničke medicinske znanosti