Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells (CROSBI ID 474673)
Prilog sa skupa u zborniku | izvorni znanstveni rad | domaća recenzija
Podaci o odgovornosti
Breljak, Davorka ; Boranić, Milivoj
engleski
Thiorphan, an inhibitor of enkephalinase (CD10) does not affect proliferation of human K562 erythroleukemia cells
This study explored the effect of thiorphan, a synthetic inhibitor of membrane metallopeptidase (enkephalinase EC 3.4.24.11, CD10) on proliferation of the human erythroleukemia cell line K562. The proliferation was measured after the incubation of the cells with thiorphan for 1 and 3 or 2, 4 and 6 days. A colorimetric assay based on the cleavage of the tetrazolium salt WST-1 by mitochondrial dehidrogenases in viable cells was used for that purpose. Thiorphan did not affect the proliferation of K562 cells, although the cells do express CD10. Thus, the CD10 membrane metallopeptidase seems not to play a significant role in the control of K562 cells proliferation rate.
erythroleukemia cell line; CD10; thiorphan; cell proliferation
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
85-87-x.
2000.
objavljeno
Podaci o matičnoj publikaciji
Current Studies in Biotechnology, Volume I. -Biomedicine
Kniewald, Zlatko i sur.
Zagreb: Croatian Society for Biotechnology
Podaci o skupu
Nepoznat skup
poster
29.02.1904-29.02.2096