engleski

Plasma homocysteine level, folate intake and bone mineral density in patients with malabsorption syndrome and the inflammatory bowel diseases

People with malabsorption syndrome and inflammatory bowel diseases are at risk for development a number of deficiencies, including vitamin B. Circulating concentration of folate, vitamin B12 and vitamin B6 are inversely associated with plasma homocysteine (Hcy). High level of plasma Hcy is one of independent risk factor for cardiovascular disease’s and assume to be in connection with bone health. Elevated plasma Hcy is a marker for functional deficiency of folate and/or vitamin B12. The aim of this study was to determine plasma Hcy level, food folate intake, folate level in serum and bone mineral density. Subjects were 20 patients with Crohn’s disease, celiac disease and ulcerous colitis (age 19-70, mean 33.6 years ; both genders). Folate intake was determined by 7-day food record. Bone mineral density (BMD) was determined by Dual energy X-ray absorptiometry. Average Hcy level was 8.7±1.86 µ mol/L. Elevated Hcy level (>10 µmol/L) had 20% of patients, while hyperhomocysteinemia was not detected. Average folate intake was according recommendation for healthy adults (400.92±183.91 µg/day). Low plasma folate level was found in 35% of patients. No statistically significant correlation was found between Hcy level and folate intake. Also there is no statistically significant correlation between folate intake and serum folate level. BMD lower then referent values were measured in 25% of patients. This can be explained by presence of nutrient malabsorption in subjects. It supports fact that recommendation for micronutrient intake should be made individually for this population and supplementation per os in not sufficient.

homocysteine; folate intake; bone mineral density

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