engleski

Native and tabun-inhibited cholinesterase interactions with oximes

We tested oximes varying in the type of ring (pyridinium and/or imidazolium), the length and type of the linker between rings, and in the position of the oxime group on the ring to find more effective oximes to reactivate tabun-inhibited human erythrocyte AChE and plasma BChE. Herein we bring an overview of in vitro interactions of native and tabun-inhibited AChE and BChE with oximes relating molecular properties of oximes to their reactivation potency

acetylcholinesterase; antidote; bioscavenger; butyrylcholinesterase; nerve agents; tabun; oxime; treatment

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