DMSA treatment during lead exposure in suckling rats (CROSBI ID 475499)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Varnai, Veda Marija ; Piasek, Martina ; Blanuša, Maja ; Matek, Marijana ; Kostial, Krista
engleski
DMSA treatment during lead exposure in suckling rats
The aim of this study was to evaluate the effect of oral DMSA treatment in suckling rats during oral lead exposure. The experiment lasted nine days and was conducted on suckling Wistar rats (day 6-14 after birth). All pups were artificially fed on cow's milk by means of a dropper, during about 6 h per day and were orally exposed to lead (as lead acetate, 2 mg Pb/kg body wt./day, administered in distilled water twice during each day ; total dose administered: 16 mg Pb/kg body wt.). Sucklings were divided into two groups: controls untreated, and experimental treated with DMSA. Each group consisted of ten pups from five different litters. DMSA was given orally at a daily dose of 0.5 mmol/kg body wt., administered twice a day, immediately after lead administration, through six days (on experimental days 1-3 and 6-8 ; total dose: 3 mmol/kg body wt.). Pups were killed by abdominal aortal exsanguination in ether anaesthesia at the end of the experiment. Lead was analysed in tissues by atomic absorption spectrometry. By DMSA treatment lead concentrations in suckling rats were significantly decreased as compared to controls in all analysed tissues: in the liver (67%), brain (56%), kidneys (40%), and carcass (27%). The finding that DMSA can be used during ongoing lead exposure might be relevant to many cases when increased lead exposure in infants and young children could not be avoided.
meso-2; 3-dimercaptosuccinic acid; lead poisoning; gastrointestinal absorption; body retention; young; rat
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Podaci o prilogu
11-11.
2000.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Abstracts from the 6th International Symposium on Chelating Agents in Pharmacology, Toxicology and Therapeutics, Biomarkers and Environment. Vol. 3, No. 3, 4
Topolčan, Ondrej
Plzeň: CECHTUMA, s.r.o.
Podaci o skupu
International Symposium on Chelating Agents in Pharmacology, Toxicology and Therapeutics (6 ; 2000)
predavanje
07.09.2000-09.09.2000
Plzeň, Češka Republika