engleski

Evoked potentials of spontaneous movements: delayed preparation in Parkinson’s disease patients

Introduction: Movement-related evoked potentials (MREPs) represent an activity that occurs mostly in brain motor areas during a movement execution. This activity emerges about 1.5 s before a movement onset and represents movement planning, preparation and execution. A spontaneous movement execution has been shown to be impaired in Parkinson’s disease (PD) patients, causing changes in their MREPs. Objectives: The aim of our study is to provide a new diagnostic tool for PD using MREPs. Considering the inconsistency of results of previously performed studies in this field, we realized the importance of choosing the group of PD patients that is as homogeneous as possible, considering patient’s age, disease severity, medication intake and other factors that might influence MREPs. Methods: Two groups of participants, PD patients (8 males, 2 females ; all right onset PD ; age 55.7+/-5.3) and healthy controls (10 males, 1 female ; age 23.45+/-0.68), were asked to perform spontaneous thumb movements repeated every 5 10 s. Electroencephalogram (EEG) was recorded and evoked potentials were extracted. Results: PD patients showed the later onset of the beginning of MREPs, known as the Bereitschaftspotential (BP) or readiness potential (RP). The BP latency delay was observed for an affected hand, but not for a healthy hand. Conclusions: This study confirmed that MREPs are influenced by PD. We were able to distinguish PD patients’ MREPs from healthy controls’ MREPs. We were also able to distinguish the side of the body affected by the disease within the PD group. Further work implies establishing normative data for MREPs of PD patients and age matched healthy controls. In future we hope to be able to monitor disease progression and assess medication efficiency.

evoked potentials; spontaneous movements; Parkinson disease

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