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Decrease of bovine acetylcholinesterase activity after the exposure to triazole pesticides (CROSBI ID 590228)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Kolesarová, Viera ; Šiviková, Katarina ; Dianovský , Ján ; Šinko , Goran ; Kovarik , Zrinka Decrease of bovine acetylcholinesterase activity after the exposure to triazole pesticides // Book of Abstracts of the XXV International Conference Genetic Days / Wierzbicki, H., Zatoń-Dobrowolska, M. (ur.). Wrocław: Department of Genetics, Wrocław University of Environmental and Life Sciences, 2012. str. 111-111

Podaci o odgovornosti

Kolesarová, Viera ; Šiviková, Katarina ; Dianovský , Ján ; Šinko , Goran ; Kovarik , Zrinka

engleski

Decrease of bovine acetylcholinesterase activity after the exposure to triazole pesticides

Triazole fugicides Orius 25EW® and Prosaro 250EC® (active substances: tebuconazole and respective tebuconazole plus prothioconazole)are used for the protection of wheat, barley and cole-seed against fungal diseases. Their fungicide effect is a result the inhibition of lanosterol 14-α-demetylase (CYP 51). The enzyme is included in ergosterol formation, an essential component of fungal cell membrane. Decrease of acetylcholinesterase (AChE) represents one of the important environmental contamination parameters. Inhibition of AChE causes the acetylcholine accumulation in synapses and neuromuscular plates and subsequent hyperactivation of brain and muscle tissue. AChE is localized in erythrocytes, synapses, neuromuscular plate and heart. Experiments were performed with bovine erythrocytes as a source of AChE. Changes in acetylcholinesterase activity were assessed spectrophotometrically after the exposure to Orius 25EW® and Prosaro 250EC® in vitro at concentrations of 50, 100, 150, 200, 250 and 300 µg.ml-1. Changes in absorbance were read and statistically evaluated by linear regression model (GraphPadPrism). Our results confirmed a high statistically significant inhibition of AChE activity (p < 0.001) in bovine erythrocytes exposed to both fungicides tested.

tebuconazole; prothioconazole; acetylcholinesterase; bovine erythrocytes

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

111-111.

2012.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstracts of the XXV International Conference Genetic Days

Wierzbicki, H., Zatoń-Dobrowolska, M.

Wrocław: Department of Genetics, Wrocław University of Environmental and Life Sciences

978-83-935303-0-4

Podaci o skupu

XXV International Conference Genetic Days

poster

18.09.2012-20.09.2012

Wrocław, Poljska

Povezanost rada

Kemija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita