The molecular links between lysosomal storage diseases and Alzheimer’s disease (CROSBI ID 605068)
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Podaci o odgovornosti
Katušić Hećimović, Silva
engleski
The molecular links between lysosomal storage diseases and Alzheimer’s disease
We analyzed the molecular links between Alzheimer's disease (AD) and Niemann-Pick type C disease (NPC) and showed that cholesterol indirectly modulates processing of the APP protein by regulating its trafficking within endocytic pathway leading to enhanced amyloidogenic APP cleavage by beta-secretase (BACE1).
Alzheimer's disease; amyloid-beta; APP; Cholesterol; Lysosomal storage; Niemann-Pick type C disease; NPC1
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Podaci o prilogu
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Podaci o skupu
Workshop New Developments of Lysosomal storage disease diagnostics & therapeutics: LSD Protein – aggregation & interactions
pozvano predavanje
14.03.2012-16.03.2012
Konstanz, Njemačka
