Endocytic traffick jam in Niemann Pick type C disease – a cause of increased Alzheimer’s amyloid-β peptide formation (CROSBI ID 605072)
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Podaci o odgovornosti
Katušić Hećimović, Silva
engleski
Endocytic traffick jam in Niemann Pick type C disease – a cause of increased Alzheimer’s amyloid-β peptide formation
We showed that cholesterol accumulation due to NPC1-loss of function causes accumulation of both APP and BACE1, the two key proteins in the pathogenesis of Alzheimer's disease, within endocytic pathway.
Alzheimer's disease; APP; amyloid-beta; lysosomal storage diseases; NPC1
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Podaci o prilogu
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Podaci o skupu
Gordon Research Conference - Lysosomal Diseases
pozvano predavanje
23.01.2011-28.01.2011
Galveston (TX), Sjedinjene Američke Države
