engleski

IgG FC GLYCOSYLATION CHANGES THROUGH LIFETIME

IgG Fc glycosylation modulates inflammation and through promotion or suppression of inflammation it may significantly contribute to the process of biological aging. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very extensive and complex changes of IgG glycosylation with age. The index composed of only three IgG glycans (FA2B, FA2G2 and FA2BG2) that considerably change with age explained 58% of variance in chronological age. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation may actually represent a factor contributing to aging.

Aging; Glycome; Glycosylation; Immunoglobulin G; Inflammation

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