hrvatski

Povezanost sastava masnih kiselina u serumu i intenziteta kliničke slike osoba oboljelih od post-traumatskog stresnog poremećaja (PTSP)

Uvod: Posttraumatski stresni poremećaj (PTSP) ubraja se, prema medicinskoj klasifikaciji, u skupinu stresom uzrokovanih poremećaja" (engl. stress related disorders) koji se može razviti kao posljedica neposredne ugroženosti ili ugroženosti bliske osobe u uvjetima rata, prirodne ili neprirodne katastrofe, teške nesreće, mučenja, silovanja i drugih. U osoba oboljelih od PTSP-a, vrlo su intenzivni simptomi anksioznosti i depresije, koji se vrlo često povezuju s promjenama u sastavu polinezasićenih masnih kiselina (PUFA) kod drugih psihičkih poremećaja. Cilj je istraživanja bio utvrditi postoji li povezanost između sastava masnih kiselina u serumu oboljelih od PTSP-a i jačine simptoma njihove kliničke slike. Materijali i metode: U istraživanju je sudjelovalo 50 veterana Domovinskog rata oboljelih od PTSP-a, izvanbolničkih pacijenata Klinike za psihijatriju Vrapče u Zagrebu. Svi su ispitanici muškog spola, prosječne dobi 44, 6 godina, u rasponu od 34 do 58 godina. Podatci za istraživanje prikupljani su u periodu od 2008. do 2010. godine. U procjeni jačine simptoma depresije i anksioznosti korištene su samoocjenske kliničke skale: Bolnička skala anksioznosti i depresije (HADS, engl. Hospital Anxiety and Depression Scale) i Beckov inventar depresije (BDI-II, engl. Beck Depression lnventory). Liječnici specijalisti psihijatrije evaluirali su jačinu oboljenja Skalom ozbiljnosti bolesti (CGI-S, engl. Clinical Global Impression - Severity of illness scale). Iz uzoraka krvi ekstrahirani su ukupni lipidi i pripremljeni metilni esteri masnih kiselina. Analiza sastava metilnih estera masnih kiselina provedena je plinsko-masenom kromatografijom (GC-MS). Statistička analiza podataka provedena je računalnim statističkim programom Statistica, verzija 12. Rezultati: Iskazana je umjerena negativna korelacija (r = -0, 595 ; P < 0, 05) jačine simptoma po HADS-D skali depresije i sadržaja dokozapentaenske kiseline (C22:5n-6) u krvi osoba oboljelih od PTSP-a te slaba pozitivna korelacija (r = 0, 460 ; P < 0, 05) simptoma depresije izraženih BDI-II skalom i ukupnog udjela mononezasićenih masnih kiselina. Zaključak: Rezultati ukazuju na moguću povezanost između sastava masnih kiselina u serumu oboljelih od PTSP-a i intenziteta simptoma anksioznosti i depressive. Objective: According to medical classification post-traumatic stress disorder (PTSD) belongs to a group of "stress related disorders" that can develop as a result of immediate threat or threat to a closely related person under conditions of vvar, natural or unnatural disasters, serious accident, torture, rape and other. Anxiety and depression are common symptoms in persons suffering from PTSD. In other psychiatric disorders they are often associated with changes in the composition of polyun- saturated fatty acids (PUFA). The aim of this study was to investigate the relationship between the fatty acid composition in the serum of patients with PTSD symptoms and severity of their clinical presentation. Methods: Ali subjects were male, the average age of 44.6 years, ranging from 34-58 years. Data for the study were collected in the period from 2008 to 2010, In assessing the severity of symptoms of depression and anxiety used clinical scale vvere used: Hospital Anxiety and Depression Scale (HADS) and Beck Depression lnventory (BDI-II). The severity of a disease was also evaluated by experienced psychiatrists using Clinical Global Impression - Severity of illness scale (CGI-S). From blood samples total lipids vvere extracted and fatty acids methyl esters were prepared. The composition of fatty acid methyl esters was analyžed by gas chromatography - mass spectrometry (GC-MS). Statistical analysis was performed using a computer statistical program Statistica, version 12. Results: Mild negative correlation (r = -0.595 ; P < 0.05) between the severity of depression symptoms according to HADS-D scale and the amount of docosapentaenoic fatty acid (C22:5n-ć) was revealed. Positive correlation (r = 0.460 ; , P < 0.05) betvveen depression symptoms according to BDI-II scale and the sum of monounsaturated fatty acids was observed. Conclusion: Results indicate possible associations betvveen fatty acid composition PTSD patients and severity of depression symptoms. Further research is necessary to confirm these findings.

anksioznost ; depresija ; psihometrijske skale ; PTSP ; PUFA

Objavljen je također i sažetak na engleskom jeziku, na str. 80 Zbornika