engleski

Importance of population features in personalized medicine: an example of metabolic syndrome

Popular question about the existence of metabolic syndrome (MetS) could be considered in terms of its differential diagnostics. As a syndrome, MetS is defined as pattern or set of risk factors, which raises your risk for heart disease and other health problems. However, MetS could be observed as a distinctive set of symptoms, which is characteristic for certain population. The main aim of this study is to compare the factor structures of risk factors (included in diagnostic criteria for MetS) in male and female inhabitants of two different regions of Croatia, stratified in those with MetS (satisfying three criteria for MetS) and healthy individuals. A total of 582 adult participants (88 male and 188 female healthy, 132 male and 174 female sick inhabitants on the island Hvar) and in total 413 (98 male and 245 female healthy, 29 male and 41 female sick inhabitants in the region Baranja), aged 18+. The variables which define the symptoms of MetS are analyzed, using exploratory strategy of PCA, according to criteria: Hvar/Baranja ; male/female and healthy/sick participants. The similarities and/or differences in factor structures among healthy and sick males/females in both locations and healthy/sick males and females in the same locations, reflect the differences in distinctive profiles of MetS in certain populations, defined by intersections of the belonging to certain region, sex and health status (MetS presence or absence). Therefore, improved interdisciplinary anthropological approach is an obligation, emphasizing the need for continuous (re)defining the MetS in certain population, especially from the historical perspective.

factor analysis; regional features; structure; symptoms; metabolic syndrome

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