Respiratory viral detection in children with cystic fibrosis (CF) (CROSBI ID 632912)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Tješić-Drinković , Ida ; Ljubin-Sternak, Sunčanica ; Vraneš, Jasmina ; Tješić-Drinković, Dorian ; Tješić-Drinković, Duška
engleski
Respiratory viral detection in children with cystic fibrosis (CF)
Objectives: The aim of this study was to assess the presence of respiratory viruses in CF patients at routine visits during the two-month period (November-December 2014) and to determine the clinical impact of this finding. Methods: Nasopharyngeal swabs/aspirates from 35 patients were tested using a PCR method (Serplex® RV15 Onestep ACE Detection), detecting 15 respiratory viruses (adenovirus, coronavirus 229E/NL63 and OC43, parainfluenza virus 1, 2, 3 and 4, influenza A and B, respiratory syncytial virus A and B, rhinovirus (RV), metapneumovirus, boccavirus and enterovirus). Results: Patients were 2-24 yrs old (AVR 12y), 13 chronically colonised with Pseudomonas aeruginosa (PA). Lung function test for 30 subjects showed: 9 normal findings ; 11 mild, 7 moderate and 3 severe lung disease. There was no significant difference regarding lung function or PA status between the subgroups of patients positive or negative for viruses. Viruses were detected in 4/35 subjects (2 RV, 1 enetrovirus, 1 parainfluenza virus 3) and 3 had concomitant PA isolation (1 chronic colonisation). However, no acute worsening of the respiratory status was found, determined as the presence of fever and upper respiratory symptoms or a recent change in at least two of the following: sputum volume or colour, cough intensity, increased malaise, increased dyspnea, loss of appetite, a decrease of FEV1 >10% (modified Fuchs criteria). Conclusion: In this pilot study chronic PA infection wasn't associated with a higher rate of viral detection and no immediate negative consequences of virus detection on the respiratory status of CF patients was observed. Further study is needed.
respiratory viruses ; cystic fibrosis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
S74-S74.
2015.
nije evidentirano
objavljeno
10.1016/S1569-1993(15)30245-9
Podaci o matičnoj publikaciji
Journal of cystic fibrosis
Elsevier
1569-1993
1873-5010
Podaci o skupu
38 Eureopean cystic fibrosis conference
poster
10.06.2015-13.06.2015
Bruxelles, Belgija
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti