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izvor podataka: crosbi

Multiclass determination of new psychoactive substances in municipal wastewater (CROSBI ID 647228)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Senta, Ivan ; Krizman, Ivona ; Ahel, Marijan ; Terzic, Senka Multiclass determination of new psychoactive substances in municipal wastewater // Pittcon Conference and Exposition : Abstracts. 2016

Podaci o odgovornosti

Senta, Ivan ; Krizman, Ivona ; Ahel, Marijan ; Terzic, Senka

engleski

Multiclass determination of new psychoactive substances in municipal wastewater

Beside the "traditional" illicit drugs, such as cocaine, heroin, and marijuana, there is a growing concern about the use of modern "designer drugs" that have emerged in large numbers over the past few years. In this work, a sensitive and selective method for simultaneous determination of 24 synthetic psychoactive compounds, including amphetamine, substituted amphetamines and cathinones, in raw wastewater (RW) and secondary effluent (SE) was developed. Samples were enriched by solid phase extraction (SPE) on mixed-mode reversed- phase/strong cation-exchange sorbent and analysed by reversed-phase liquid chromatography coupled to electrospray ionisation tandem mass spectrometry (LC-MS/MS). The target compounds were separated on a Synergi Hydro column and detected using multiple reaction monitoring (MRM) in positive polarity. Reliable quantification was achieved by using several deuterated analogues as surrogate standards. Careful optimisation and validation of the procedure resulted in a reliable determination of all target analytes in low ng/L range for both RW and SE, which makes the method suitable for the application in sewage epidemiology. The method was applied for assessment of selected compounds in municipal wastewater from Croatia. It was shown that the well-known synthetic illicit drugs, amphetamine and MDMA still dominate in all samples (concentrations up to 545 ng/L and 55 ng/L in RW, respectively), while the new psychoactive substances were detected very rarely in low concentrations.

Drugs ; Environmental, Waste and Sludge ; Liquid Chromatography/Mass Spectroscopy ; Solid Phase Extraction

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Podaci o prilogu

1330-4

2016.

objavljeno

Podaci o matičnoj publikaciji

Pittcon Conference and Exposition : Abstracts

Podaci o skupu

Pittcon Conference

predavanje

06.03.2016-10.03.2016

Atlanta (GA), Sjedinjene Američke Države

Povezanost rada

Geologija, Kemija

Poveznice