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izvor podataka: crosbi

Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry (CROSBI ID 240610)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Senta, Ivan ; Krizman, Ivona ; Terzić, Senka ; Ahel, Marijan Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry // Journal of Chromatography A, 1509 (2017), 60-68. doi: 10.1016/j.chroma.2017.06.005

Podaci o odgovornosti

Senta, Ivan ; Krizman, Ivona ; Terzić, Senka ; Ahel, Marijan

engleski

Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry

Macrolide antibiotics are a prominent group of emerging contaminants frequently found in wastewater effluents and wastewater-impacted aquatic environments. In this work, a novel analytical method for simultaneous determination of parent macrolide antibiotics (azithromycin, erythromycin, clarithromycin and roxithromycin), along with their synthesis intermediates, byproducts, metabolites and transformation products in wastewater and surface water was developed and validated. Samples were enriched using solid-phase extraction on Oasis HLB cartridges and analyzed by reversed-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry. The target macrolide compounds were separated on an ACE C18 PFP column and detected using multiple reaction monitoring in positive ionization polarity. The optimized method, which included an additional extract clean-up on strong anion-exchange cartridges (SAX), resulted in high recoveries and accuracies, low matrix effects and improved chromatographic separation of the target compounds, even in highly complex matrices, such as raw wastewater. The developed method was applied to the analysis of macrolide compounds in wastewater and river water samples from Croatia. In addition to parent antibiotics, several previously unreported macrolide transformation products and/or synthesis intermediates were detected in municipal wastewater, some of them reaching μg/L levels. Moreover, extremely high concentrations of macrolides up to mg/L level were found in pharmaceutical industry effluents, indicating possible importance of this source to the total loads into ambient waters. The results revealed a significant contribution of synthesis intermediates and transformation products to the overall mass balance of macrolides in the aquatic environment.

Antibiotics ; Azithromycin ; Erythromycin ; Clarithromycin ; Transformation products ; Liquid chromatography–tandem mass spectrometry ; Wastewater ; Surface water

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Podaci o izdanju

1509

2017.

60-68

objavljeno

0021-9673

10.1016/j.chroma.2017.06.005

Povezanost rada

Geologija, Kemija

Poveznice
Indeksiranost