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izvor podataka: crosbi

Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index (CROSBI ID 250619)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Doganis, Dimitrios ; Panagopoulou, Paraskevi ; Tragiannidis, Athanasios ; Georgakis, Marios K. ; Moschovi, Maria ; Polychronopoulou, Sofia ; Rigatou, Efthimia ; Papakonstantinou, Eugenia ; Stiakaki, Eftichia ; Dana, Helen et al. Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index // Cancer Epidemiology, 54 (2018), 75-81. doi: 10.1016/j.canep.2018.03.012

Podaci o odgovornosti

Doganis, Dimitrios ; Panagopoulou, Paraskevi ; Tragiannidis, Athanasios ; Georgakis, Marios K. ; Moschovi, Maria ; Polychronopoulou, Sofia ; Rigatou, Efthimia ; Papakonstantinou, Eugenia ; Stiakaki, Eftichia ; Dana, Helen ; Bouka, Evdoxia ; Antunes, Luis ; Bastos, Joana ; Coza, Daniela ; Demetriou, Anna ; Agius, Domenic ; Eser, Sultan ; Ryzhov, Anton ; Šekerija, Mario ; Trojanowski, Maciej ; Zagar, Tina ; Zborovskaya, Anna ; Perisic, Snezana Zivkovic ; Stefanaki, Kalliopi ; Dessypris, Nick ; Petridou, Eleni Th.

engleski

Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index

BACKGROUND: Despite advances in the management of nephroblastoma (Wilms' tumor, WT), the etiology of the tumor remains obscure. We aimed to compare nephroblastoma incidence rates and time trends among children (0-14 years) in 12 Southern and Eastern European (SEE) countries and the Surveillance, Epidemiology, and End Results Program (SEER), USA, in relation to the human development index (HDI). METHODS: In total 1776 WT cases were recorded in 13 SEE collaborating registries (circa 1990-2016), whereas data on 2260 cases (1990-2012) were extracted from the SEER database. Age- standardized incidence rates (AIRs) were calculated and correlated with HDI, whereas temporal trends were evaluated using Poisson regression and Joinpoint analyses. RESULTS: The overall SEE AIR (9.2/106) was marginally higher than that of the SEER (8.3/106), whereas significant differences were noted among the 13 SEE registries which comprised mainly Caucasian populations. A statistically significant temporal increase in incidence was noted only in Belarus. Most cases (∼75%) were diagnosed before the fifth year of life, with rates steadily declining thereafter ; median age at diagnosis was similar in SEE countries and SEER. A slight male preponderance in the first year of life (male:female = 1.1) was followed by a female preponderance in the older age groups (male:female = 0.7). Lastly, a statistically significant positive association between higher HDI and increasing nephroblastoma incidence was noted (regression coefficient: +3.25, 95%CI: +1.35, +5.15). CONCLUSIONS: Variations in incidence and time trends across the examined registries, changing male-to-female patterns with advancement in age, and positive associations with the HDI imply a plausible role for environmental and genetic factors in disease etiology, and these need to be explored further.

childhood ; gender differentials ; human development index ; incidence ; inequalities ; nephroblastoma ; time trends

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

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Podaci o izdanju

54

2018.

75-81

objavljeno

1877-7821

10.1016/j.canep.2018.03.012

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

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