Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Structural Characterization of Impurities in 3- Bromo-5-(trifluoromethyl)aniline by LC-SPE/NMR (CROSBI ID 672903)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Harča, Miroslava ; Habinovec, Iva ; Meštrović, Ernest ; Biljan, Ivana ; Novak, Predrag Structural Characterization of Impurities in 3- Bromo-5-(trifluoromethyl)aniline by LC-SPE/NMR // 25. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Šantić, Ana ; Đaković, Marijana (ur.). Zagreb: Hrvatsko kemijsko društvo, 2017. str. 251-251

Podaci o odgovornosti

Harča, Miroslava ; Habinovec, Iva ; Meštrović, Ernest ; Biljan, Ivana ; Novak, Predrag

engleski

Structural Characterization of Impurities in 3- Bromo-5-(trifluoromethyl)aniline by LC-SPE/NMR

Impurities define the quality of a chemical entity so their unambiguous structure determination is essential part of the pharmaceutical development. Liquid chromatography (LC) – solid-phase extraction (SPE) / nuclear magnetic resonance (NMR) methodology with cryoprobe was developed and applied for identification and structural characterization of unknown impurities in 3-bromo- 5-(trifluoromethyl)aniline. The three main impurities were separated and isolated by LC-SPE system. After multiple trapping, isolated impurities were eluted from the SPE cartridges with deuterated acetonitrile and one- and two- dimensional homo- and heteronuclear NMR spectra were recorded. The structures of the unknown impurities were determined by detailed inspection of NMR spectra and by mass spectrometric (MS) analysis to show that the impurities in question are di-bromo derivatives of 3- (trifluoromethyl)aniline. The results demonstrated that LC-SPE / NMR can be used for rapid impurity profiling of 3-bromo-5-(trifluoromethyl)aniline.

LC-SPE, NMR, Structural characterization, Impurities

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

251-251.

2017.

objavljeno

Podaci o matičnoj publikaciji

25. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka

Šantić, Ana ; Đaković, Marijana

Zagreb: Hrvatsko kemijsko društvo

Podaci o skupu

25. hrvatski skup kemičara i kemijskih inženjera

poster

19.04.2017-22.04.2017

Poreč, Hrvatska

Povezanost rada

Kemija

Poveznice