Successful use of recombinant activated factor VII in refractory gastrointestinal haemorrhage of unknown aetiology (CROSBI ID 144986)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Matić, Ivo ; Titlić, Marina ; Lučić, Ivan, Mirković, Ivo ; Jurjević, Matija
engleski
Successful use of recombinant activated factor VII in refractory gastrointestinal haemorrhage of unknown aetiology
We report a 27-year-old patient who suffered severe gastrointestinal (GI) bleeding of unknown aetiology after undergoing elective abedominal surgery to remove a colonic tumour. Although the immediate postoperative recovery period was uneventful, rectal bleeding and signs of haemorrhagic shock developed within 10 hours of surgery. Nasogastric aspiration and laparotomy failed to reveal thecause of the GI haemorrhage, and the patient remained unresponsive to conventional haemostatic therapy. Treatment with a single dose of recombinant activated factor (rFVIIa) 45 ug/kg led to reduced bleeding, improvements in haemodynamic status, and reduced transfusion requirements. Although further investigation is warranted, our findings suggest that rFVIIa may be useful in the rescue treatment of severe GI haemorrhage of unknown origin.
gastrointestinal haemorrhage ; haemostatics ; laparotomy ; erythocyte transfusion
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti