Life-threatening Valproate Overdose Successfully Treated with Haemodialysis (CROSBI ID 145125)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Meštrović, Julije ; Filipović, Tomislav ; Polić, Branka ; Stričević, Luka ; Omazić, Ante ; Kuzmanić-Šamija, Radenka ; Markić, Joško
engleski
Life-threatening Valproate Overdose Successfully Treated with Haemodialysis
Valproate (VPA) poisoning is an increasing clinical problem. The most common finding in VPA overdose is the depression of the central nervous system, which may progress to coma and death. This type of poisoning is difficult to treat, as no antidote exists. This report describes a case with a 16-year-old girl who poisoned herself with valproate. Initial treatment included naloxone, but she did not respond. She became comatose, with serum VPA concentration of 1320 µ ; ; g mL-1. Three sessions of haemodialysis were performed, effectively eliminating VPA and decreasing the serum concentration. The patient regained consciousness and fully recovered. To our knowledge, this is the highest serum VPA concentration reported by now in children aged 16 or less. Haemodialysis has proved to be the treatment of choice for life-threatening acute VPA overdose in children.
central nervous system depressants; intensive care; thrombocytopenia; toxicity
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Podaci o izdanju
59 (4)
2008.
295-298
objavljeno
0004-1254
10.2478/10004-1254-59-2008-1884
Povezanost rada
Kliničke medicinske znanosti