engleski

Comparative analysis of gallium in human hair and blood

Gallium (Ga) is a relatively rare non-essential trače metal that has found uses in diagnostic radiology, and as an antineoplatic agent, and for the control of cancer-related hypercalcemia. We studied the distribution of gallium in the hair and whole blood of 96 occupationally non-exposed subjects (38 men, 58 women). The study was conducted following the declaration of Helsinki on the ethics of the human subject research. Gallium analysis was performed by ICP-MS at the CBM, Moscow, Russia, an ISO certified analytical laboratory. International certified standards for hair and whole blood analysis were used for the control. Median gallium concentration in the hair was 0.026 |ig/g (men: 0.020 jog/g, women: 0.039 (j, g/g) whereas median concentration of gallium in the blood was 0.003 |ig/g"' (the same for both men and women). More women than men have their hair gallium above the median (P < 0.01 by chi-square) vvhereas there were no statistically significant differences between men and women recorded in the whole blood. The results showed the importance of assessing gallium in hair. Hair appears to be a more sensitive indicator tissue for assessing gallium metabolism the whole blood. The reason for observed difference of greater gallium accumulation in men than women remains to be elucidated.

gallium; hair; blood; gender difference

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