Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Exposure to cadmium and effects on placental steroidogenesis in rats: comparing oral versus parenteral route of exposure (CROSBI ID 590208)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Mikolić, Anja ; Kralik Oguić, Saša ; Kušec, Vesna ; Piasek, Martina Exposure to cadmium and effects on placental steroidogenesis in rats: comparing oral versus parenteral route of exposure // Arhiv za higijenu rada i toksikologiju / Želježić, Davor (ur.). 2012. str. 36-x

Podaci o odgovornosti

Mikolić, Anja ; Kralik Oguić, Saša ; Kušec, Vesna ; Piasek, Martina

engleski

Exposure to cadmium and effects on placental steroidogenesis in rats: comparing oral versus parenteral route of exposure

Cadmium is a toxic environmental pollutant with potential to act as an endocrine-disrupting chemical in reproductive organs. Main sources of cadmium exposure in general population are contaminated food, water, and tobacco smoke. Up to 50% of the inhaled cadmium and an average of 5% (<1% to >20%) of cadmium oral intake is absorbed, which depends on age, nutrition, and physiological state. In exposed mammals, including humans, cadmium accumulated in placental tissue can disrupt its vital function of hormones’ synthesis during gestation. We compared effects of oral vs. parenteral cadmium route of exposure on placental steroidogenesis in laboratory rats. Previous investigation showed cadmium effects on placental progesterone production in rats (Sprague Dawley) after 19-day exposure during pregnancy at total doses of 3 or 5 mg Cd/kg b.wt sc. by osmotic pumps (Piasek et al., TEMA 10, 2000, pp. 809-12). In our new investigation, rats (Wistar) with regular four-day estrous cycle were exposed orally to 50 ppm Cd (as chloride ; 7.26±0.86 mg Cd/kg b.wt) from gestation day 1 to 20. Mother rats were then euthanized and placentas dissected, weighed, and prepared for cadmium analysis (by atomic absorption spectrometry) and steroid hormone assay (by enzyme-immunometric method). Cadmium increased in placentas of exposed rats by both routes of exposure. While parenteral cadmium exposure decreased placental progesterone, oral exposure increased progesterone concentrations in rat placentas. In conclusion, cadmium disrupts placental progesterone synthesis, which may compromise pregnancy outcome and foetal viability. This effect depends on the route of exposure during pregnancy.

cadmium exposure; placental progesterone; pregnancy; steroid disruption

Poster presentation P-17

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

36-x.

2012.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Arhiv za higijenu rada i toksikologiju

Želježić, Davor

0004-1254

Podaci o skupu

4th Croatian Congress of Toxicology with the international participation

poster

02.10.2012-05.10.2012

Primošten, Hrvatska

Povezanost rada

Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Poveznice
Indeksiranost