Correlation between mean platelet volume and total risk of cardiovascular disease (CROSBI ID 378581)
Ocjenski rad | diplomski rad
Podaci o odgovornosti
Marković, Domagoj
Fabijanić, Damir
engleski
Correlation between mean platelet volume and total risk of cardiovascular disease
Introduction: Association between mean platelet volume (MPV) and single cardiovascular diseases (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods: In 216 consecutive outpatients referred to cardiology examination because of multiple CVD risk factors total CVD risk was estimated according to the Framingham Risk Score (FRS) as a low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in FRS equation. Also, CVD risk was estimated according to tertile of MPV (<8.3, 8.3-9.1, >9.1 fL, respectively). Correlation between hs-CRP and FRS has been used as confirmation that our study hypothesis was properly set. Results: MPV did not correlate with individual CVD risk factors or with FRS, either before, nor after adjustment for additionally CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group ; namely, for persons in tertile 3 were noted doubled increase in CVD risk (OR 2.2 ; 95% CI 1.05-4.64 ; p=0.038). In comparison, there was a strong linear correlation between hs-CRP and unadjusted (r=0.203, p=0.004) and adjusted (r=0.383, p<0.001) FRS. Conclusion: Correlation between MPV with only high total CVD risk suggest increased platelet activity primary as consequence and sign of the atherosclerotic vascular damage. Linear correlation between hs-CRP with FRS confirm inflammation as an important mechanism of atherogenesis,
Platelets; Cardiovascular risk; Atherosclerosis
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Podaci o izdanju
23
04.07.2013.
obranjeno
Podaci o ustanovi koja je dodijelila akademski stupanj
Medicinski fakultet u Splitu
Split