engleski

Low-grade inflammation and iron metabolism in chronic kidney disease (CKD) patients

Background: Patients with CKD are exposed to persistent low-grade inflammation. Increased level of proinflammatory cytokines cause cellular iron retention and repress iron efflux from sites of main iron flow into the blood reducing thus iron availablity and contributing to development of anemia in CKD patients. This study aimed to assess relationship between indicators of inflammation and routine biochemical markers of iron metabolism as well as hematological indicators of iron availability in group of HD patients with low-grade inflammation (defined as CRP < 15 mg/L, without clinical manifestation of inflammation). Materials and methods: The study was conducted in 45 HD patients and 21 healthy subjects. Biochemical markers (serum iron, transferrin, transferrin saturation, ferritin), haematological indexes (%Hypo and CHr) were determined by routine laboratory methods. As inflammatory markers, CRP and hsIL-6 were determined. Results: Levels of serum CRP (2.9 (0.9-10.9) vs. 0.8 (0.4-3.2) mg/L) and IL-6 (5.03 (1.69-10.5 vs. 1.20 (0.14-10.55 ng/L) were significantly higher in HD patients compared with control group (P < 0.05). We found a statistically significant (P < 0.05) lower level of serum iron, transferrin, transferrin saturation and higher level of ferritin and %Hypo but there were no significant correlations between CRP/IL-6 and biochemical markers of iron status or hematological indexes in HD group. Conclusion: Parameters of iron metabolism are changed but inflammation indicators do not correlate with parameters of iron metabolism in our studied group. Since levels of serum inflammatory markers are subjected to a substantial variability over time repeated versus single measurements in a future studies could give a more valuable information about examined relationship.

Inflamation; iron; CKD

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