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An update on the management of young-onset Parkinson's disease (CROSBI ID 210626)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Klepac, Nataša ; Habek, Mario ; Adamec, Igor ; Barušić, Anabela Karla ; Bach, Ivo ; Margetić, Eduard ; Lušić, Ivo An update on the management of young-onset Parkinson's disease // Degenerative neurological and neuromuscular disease, 3 (2013), 53-62. doi: 10.2147/DNND.S34251

Podaci o odgovornosti

Klepac, Nataša ; Habek, Mario ; Adamec, Igor ; Barušić, Anabela Karla ; Bach, Ivo ; Margetić, Eduard ; Lušić, Ivo

engleski

An update on the management of young-onset Parkinson's disease

In the text that follows, we review the main clinical features, genetic characteristics, and treatment options for Parkinson's disease (PD), considering the age at onset. The clinical variability between patients with PD points at the existence of subtypes of the disease. Identification of subtypes is important, since a focus on homogenous group may lead to tailored treatment strategies. One of the factors that determine variability of clinical features of PD is age of onset. Young-onset Parkinson's disease (YOPD) is defined as parkinsonism starting between the ages of 21 and 40. YOPD has a slower disease progression and a greater incidence and earlier appearance of levodopa-induced motor complications ; namely, motor fluctuations and dyskinesias. Moreover, YOPD patients face a lifetime of a progressive disease with gradual worsening of quality of life and their expectations are different from those of their older counterparts. Knowing this, treatment plans and management of symptoms must be paid careful attention to in order to maintain an acceptable quality of life in YOPD patients.

Parkinson disease ; management ; therapy ; clinical features ; dopamine agonist ; levodopa ; dyskinesia

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Podaci o izdanju

3

2013.

53-62

objavljeno

1179-9900

10.2147/DNND.S34251

Povezanost rada

Kliničke medicinske znanosti

Poveznice