engleski

Long-term therapy with proton pump inhibitors is associated with decreased bone density

It is well known that bone density is determined by the interrelationship of many factors in the human organism. A number of these factors act on general level (parathyreoid hormone, thyreoid hormones, growth hormone, sex hormones, and vitamin D). There are also various other factors (prostaglandines, interleukines, and growth factors) which act on local level. All of these factors influence bone density by stimulating or inhibiting the bone remodeling process. This process is regulated through the osteoprotegerin molecule (OPG-RANKL system), which activates osteoclasts.  It was reported that bone turnover is decreased in patients treated with PPI. We hypothesized that long-term therapy is associated with decreased bone density, consequently with osteoporosis and fractures

Long therm therapy; proton pump inhibitors; bone density

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