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izvor podataka: crosbi

Expression of matrix metalloproteinase-9 in patients with squamous cell carcinoma of the larynx (CROSBI ID 210918)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Colović, Zavisa ; Pešutić-Pisac, Valdi ; Poljak, Nikola Kolja ; Račić, Goran ; Cikojević, Draško ; Kontić, Mirko Expression of matrix metalloproteinase-9 in patients with squamous cell carcinoma of the larynx // Collegium antropologicum, 37 (2013), 1; 151-155

Podaci o odgovornosti

Colović, Zavisa ; Pešutić-Pisac, Valdi ; Poljak, Nikola Kolja ; Račić, Goran ; Cikojević, Draško ; Kontić, Mirko

engleski

Expression of matrix metalloproteinase-9 in patients with squamous cell carcinoma of the larynx

Aim of this study was to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma, and to assess the role of MMP-9 expression in patient survival. Study included 196 patients with squamous cell carcinoma of the larynx treated at ENT Department, Split University Hospital Centre, from January 1, 2000 till December 31, 2009. The level of MMP-9 expression showed a statistically significant correlation (p < 0.001) with the disease histopathologic grade, stage, metastatic potential, recurrence potential, and survival. Kaplan-Meier curve yielded a statistically significant survival difference (p < 0.001) among the three patient groups with different levels of MMP-9 expression. The survival curve clearly showed the MMP-9 expression as a predictor of survival to be significantly (p < 0.001) associated with survival. In this study, MMP-9 expression as a biological marker showed a potential predictive value in laryngeal squamous cell carcinoma.

matrix metalloproteinase-9; squamous cell carcinoma; larynx

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Podaci o izdanju

37 (1)

2013.

151-155

objavljeno

0350-6134

Povezanost rada

Kliničke medicinske znanosti

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