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Streptococcus pneumoniae resistance in children (CROSBI ID 629827)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Pavlov , Neven ; Kaliterna , Vanja ; Šitum , Marijan ; Tonkić , Marija ; Dragišić-Ivulić , Slavica Streptococcus pneumoniae resistance in children // The European respiratory journal. Supplement / European Respiratory Society (ur.). 1999. str. 452-453

Podaci o odgovornosti

Pavlov , Neven ; Kaliterna , Vanja ; Šitum , Marijan ; Tonkić , Marija ; Dragišić-Ivulić , Slavica

engleski

Streptococcus pneumoniae resistance in children

We researched retrospectively frequency of airways infection in children hospitalised in Department of Pediatrics during 1997 caused by Streptococcus pneumoniae (SP) and its antibiotic susceptibility. Antibiotic susceptibility of SP was defined by disc diffusion technique, using 1 mcg oxacillin disc, with 25 mm cut of zone. Total number of hospitalised children was 2499 and 792 (32%) had respiratory tract infection (RTI). Nasal and pharyngeal swabs were analysed from 489 children (62% of children with RTI). Positive bacteriological culture was found in 186 children (38%). 223 pathogens were isolated (23% of all swabs): SP in 53 (24%), Staphylococcus aureus (SA): 80 (36%), Haemophylus influenzae in 36 (16%), Streptococcus pyogenes in 35 (16%) and others in 19 (8%) of all isolates. SP was isolated from 53 swabs of 46 children, 27 (51%) from pharyngeal swabs, 25 (47%) from nasal swabs and 1 (2%) from blood culture. 7 children (13%) had SP isolated from both swabs. Resistance of SP to benzylpenicillin was found in 73, 6%, to Azithromycin in 28, 1%, to Cotrimoxazole in 27%, to Erythromycin in 19, 4%, to Cefotaxime in 17% and to Clindamycin in 8%. SP showed moderate sensitivity to Ceftriaxone in 16, 3%, to Cotrimoxazole in 14%, to Erythromycin in 6, 4% and to Azithromycin in 3, 1%. SP was sensitive to benzylpenicillin in 26, 4%, to Vancomycin in 100%, to Clindamycin in 92%, to Ceftriaxone in 83, 7%, to Erythromycin in 74, 2%, to Azithromicin in 68, 8% and Cotrimoxazole in 59%. Conclusion: The presented results confirm that RTI are the most frequent disease among children (32% of all hospitalised children). SA is the most frequent isolated pathogen (35, 9%), then SP (23, 75%). Penicillin resistance of SP is high (73, 6%). It is necessary to define MIC for beta-laktams of clinical important isolates and to correct initial antibiotic therapy in RTI caused by SP.

Streprococcus pneumoniae; Resistance; Children

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Podaci o prilogu

452-453.

1999.

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objavljeno

Podaci o matičnoj publikaciji

The European respiratory journal. Supplement

European Respiratory Society

Madrid: European Respiratory Society

0904-1850

Podaci o skupu

ERS Annual Congress Madrid 1999

poster

09.10.1999-13.10.1999

Madrid, Španjolska

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost