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izvor podataka: crosbi

Inhibition of the HIV-1 Rev-RRE Complex Formation by Unfused Aromatic Cations (CROSBI ID 101031)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Xiao, Ge ; Kumar, Arvind ; Li, Ke ; Rigl, C Ted ; Bajić, Miroslav ; Davis, Tina M ; Boykin, David W ; Wilson W David Inhibition of the HIV-1 Rev-RRE Complex Formation by Unfused Aromatic Cations // Bioorganic & medicinal chemistry, 9 (2001), 5; 1097-1113-x

Podaci o odgovornosti

Xiao, Ge ; Kumar, Arvind ; Li, Ke ; Rigl, C Ted ; Bajić, Miroslav ; Davis, Tina M ; Boykin, David W ; Wilson W David

engleski

Inhibition of the HIV-1 Rev-RRE Complex Formation by Unfused Aromatic Cations

RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.

small molecules; ribosomal-RNA; responsive element; recognize RNA; drug target; binding; antibiotics; tat; protein; design

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Podaci o izdanju

9 (5)

2001.

1097-1113-x

objavljeno

0968-0896

Povezanost rada

Kemija

Indeksiranost