Novel diastereomeric thymidine cyclic 3', 5'-threo-phosporamidates (CROSBI ID 80974)
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Katalenić, Darinka ; Žinić, Mladen
engleski
Novel diastereomeric thymidine cyclic 3', 5'-threo-phosporamidates
Novel diastereomeric thymidine cyclic 3', 5'-threo-phosphoramidates were prepared by the treatment of 5'-azido derivative of threo-thymidine with triphenyl phosphite as well as by the treatment of the corresponding amino derivative with phenyl phosphodichloridate. Phosphoramidation of the regioisomeric 3'- and 5'-azido derivatives of erythro-thymidine by means of triphenyl phosphite afforded the open-chain 3'- and 5'-phosphoramidates. The reaction which afforded the cyclic products was assumed to proceed via the cyclic tetraoxazaphosphorane intermediates.
nucleosides ; thymidine ; phosphoramidates
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