engleski

In Vitro Inhibition of Membrane-Mediated Calcification by Novel Posphonates

The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine, dicetylphosphate, cholesterol liposomal model is reported. The investigated phosphonates did not significantly delay the initial formation of hydroxyapatite-like calcium phosphate salts within the liposomes or the penetration of this crystals through the enclosing membranes. However, the phosphonates variably retarded the subsequent growth and proliferation of crystals once they became directly exposed to the phosphonate- containing solutions. The effectiveness of phosphonates in inhibiting extraliposomal precipitation strongly depended on their structure.

geminal bisphosphonates ; bone donors ; hydroxyapatite ; calcium metabolism disorder

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