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The influence of lower alcohols on the surface lipid monolayer in LDL (CROSBI ID 81454)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kveder, Marina ; Pifat, Greta ; Pečar, Slavko ; Schara, Milan The influence of lower alcohols on the surface lipid monolayer in LDL // Croatica chemica acta, 71 (1998), 1; 189-198

Podaci o odgovornosti

Kveder, Marina ; Pifat, Greta ; Pečar, Slavko ; Schara, Milan

engleski

The influence of lower alcohols on the surface lipid monolayer in LDL

Interaction of methanol, ethanol, propanol and butanol with human plasma low density lipoproteins (LDL) was studied in this work. The surface lipid monolayer of LDL was spin labeled and the electron spin resonance (ESR) spectra were measured in the presence and absence of alcohols. The decomposition of the complex ESR spectra was performed via theoretical simulations of experimental data. The results gained from this study indicate that the influence of alcohol could be observed through the changes of lipid ordering in the surface of LDL monolayer. This observation supports the hypothesis on the mechanism of alcohol action through its interference with lipid-protein interactions at the level of macromolecular surface.

LDL ; ESR ; EPR

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Podaci o izdanju

71 (1)

1998.

189-198

objavljeno

0011-1643

Povezanost rada

Kemija

Poveznice
Indeksiranost