engleski

Non-natural phenolic amino acids. Synthesis and application in peptide chemistry

Several non-natural phenolic amino acids have been synthesized. t-Butylated tyrosine and thyroxine derivatives, on one-electron oxidation, give persistent radicals which can be used as positional and/or spin labels for amino acids. Two-electron oxidation of N-protected tyrosines leads to spirolactones, useful active esters for peptide coupling.

amino acids; spirolactones

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