engleski

Analysis of the in vitro secretory activity of human pituitary adenomas : modification of corticotropin release from adenoma tissue explant cultures by addition of a human plasma ultrafiltrate bioactive fraction

The use of tissue explant cultures of human pituitary adenomas and the comparison of the feature of cultured tumours with their behaviour in vivo showed that corticotropin is released not only from the tumours associated with Cushing's disease, but also from clinically non-functioning tumours. The results suggest that "human plasma ultrafiltrate bioactive fraction"could be one of the humoral factors involved in the regulation of corticotropin release from pituitary adenoma tissue. Its possible involvement in the regulation of corticotropin release from normal pituitary tissue, however, is uncertain.

adenocorticotropin secretion ; extracellular calcium ; glycoprotein hormone ; kinetic profile ; cells ; somatostatin ; stimulation ; peptide ; tumour

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