Pyridyl and furyl epoxides of more than 99% enantiomeric purities: The use of a phosphazene base (CROSBI ID 85735)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Solladie-Cavallo, Arlette ; Isarno, Thomas ; Roje, Marin ; Vinković, Vladimir ; Šunjić, Vitomir
engleski
Pyridyl and furyl epoxides of more than 99% enantiomeric purities: The use of a phosphazene base
trans-1-(2-Pyridyl)-, trans-1-(3-pyridyl)-, trans-1(2-furyl)-, and trans-1(3-furyl)-2-phenyl epoxides with enantiomericpurities ranging from 96.8 to 99.8% [in favor of the (+, EtOH)-isomer] are obtained in two steps from pure (R, R, R)-oxathi-ane which is recovered (85– 90%) and reused. The chiral bidentate ligand 2-phenyl-(S)-1-(2-pyridyl)ethanol with 99.6% ee was obtained in three steps and 67% overall isolated yield.
Asymmetric synthesis ; Phosphazene base ; Pyridyl epoxide ; Furyl epoxide ; Pyridyl alcohol
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Podaci o izdanju
2000 (6)
2000.
1077-1080
objavljeno
1434-193X
1099-0690
10.1002/(SICI)1099-0690(200003)2000:6<1077::AID-EJOC1077>3.0.CO;2-4