Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding (CROSBI ID 25032)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Tomić, Sanja ; Nillson, Lennart ; Wade, Rebecca
engleski
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding
To identify the major determinants of the DNA binding specificity of nuclear transcription factors, the Comparative Binding Energy (COMBINE) analysis has been performed. 3DQSAR models were derived for a set of 320 complexes of DNA and glucocorticoid receptor mutants, and the parameters important for determining binding specificity were identified.
Quantitative Structure-Activity Relationship (QSAR), COMBINE analysis, molecular modeling, gene regulation, molecular mechanics
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Podaci o prilogu
269-270-x.
objavljeno
Podaci o knjizi
Molecular Modeling and Prediction of Bioactivity
Gudertofte, K ; Jorgensen, F. S.
New York (NY): Kluwer Academic Publishers ; Plenum Publishers
2000.
0-306-46217-6