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Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia (CROSBI ID 86737)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Brozović, Anamaria ; Šimaga, Šumski ; Osmak, Maja Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia // Neoplasma, 48 (2001), 2; 99-103-x

Podaci o odgovornosti

Brozović, Anamaria ; Šimaga, Šumski ; Osmak, Maja

engleski

Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia

The altered constitutive and inducible levels of heat shock proteins 70 (Hsp70) in drug-resistant cells may influence the efficiency of combined hyperthermia and anticancer drug treatment. In the present study, the constitutive levels of Hsp70 and induction of these proteins by hyperthermia and two anticancer drugs (used for resistance development) were determined in cervical and laryngeal carcinoma cells. The levels of Hsp 70 were quantified by Western blot. Constitutive levels of Hsp70 were similar in parental and drug-resistant cervical and laryngeal carcinoma cells suggesting that Hsp70 may not be involved in drug-resistance. Hyperthermic treatment induced Hsp70 in all examined cell lines but with different kinetics in drug-resistant cells and parental cells. Following the treatment with anticancer drugs, Hsp70 was induced only in cisplatin-resistant laryngeal cells. Kinetics of Hsp 70 induction ( stress-type and cell-type specific) was different in drug-resistant cells as compared to parental cells. The observed alterations in Hsp 70 induction in drug resistant and parental cells should be taken into account when combined treatments ( i.e. hyperthermia and anticancer drugs) are planned.

heat shock protein 70; drug-resistance; cisplatin; vincristine; hyperthermia

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Podaci o izdanju

48 (2)

2001.

99-103-x

objavljeno

0028-2685

Povezanost rada

Kemija, Biologija

Indeksiranost